Citrus Magic

Citrus fruits are product of trees and shrubs from family of plants, Rutaceae, including orange, lemon, lime, grapefruit, mandarin, and pomelo. 

They are good sources of nutrients, particularly of vitamin C. In addition to vitamin C, which is the most abundant nutrient, these fruits are a source of B vitamins (thiamin, pyridoxine, niacin, riboflavin, pantothenic acid, and folate). Furthermore, citrus fruits are abundant in macronutrients - sugars, dietary fiber, potassium, folate, calcium, phosphorus, magnesium, copper, riboflavin and pantothenic acid. 

Citrus fruits contain a number of secondary metabolites, such as flavonoids, alkaloids, coumarins, limonoids, carotenoids, phenol acids and essential oils. These biochemicals play a vital role in human health and show important activity in human body, including anti-oxidative, anti-inflammatory, anti-cancer, as well as cardiovascular protective effect. Studies of bioactivity of flavonoids have been extensively reported in last 50 years.

Citrus fruits have been used in traditional and modern medicine and nutrition as a source of very important biochemicals supporting human health, particularly cardiovascular health, with its strong anti-oxidant activity, vascular protective effect, and its vascular function improvement effect. 

1. Katherine A. Lyseng-Williamson and Caroline M. Perry Micronised Purified Flavonoid Fraction. A Review of its Use in Chronic Venous Insufficiency, Venous Ulcers and Haemorrhoids. Drugs 2003; 63 (1): 71-100

2. Diosmin Monograph. Alternative Medicine Review 2004, Volume 9, Number 3

3. Hesperidin. Natural Medicines Database. Professional Monograph. 2/13/2019

4. The British Journal of Surgery: Meta-Analysis of Flavonoids for the Treatment of Haemorrhoids

5. Ramelet AA. Clinical benefits of Daflon 500mg in the most severe stages of chronic venous insufficiency. Angiology 2001;52:S49-S56.

6. Smith PD. Neutrophil activation and mediators of inflammation in chronic venous insufficiency. J Vasc Res 1999;36:24-36.

7. Bergan JJ, Schmid-Schonbein GW, Takase S. Therapeutic approach to chronic venous insufficiency and its complications: place of Daflon 500 mg. Angiology 2001;52:S43-S47.

8. Le Devehat C, Khodabandehlou T, Vimeux M, Kempf C. Evaluation of haemorheological and microcirculatory disturbances in chronic venous insufficiency: activity of Daflon 500mg. Int J Microcirc Clin Exp 1997;17:27-33.

9. Yoichi Nogata et al. Flavonoid Composition of Fruit Tissues of Citrus Species. Bioscience, Biotechnology, and Biochemistry Vol. 70 (2006) , No. 1 pp.178-192

10. Amílcar Duarte et al. Citrus as a Component of the Mediterranean Diet. Journal of Spatial and Organizational Dynamics, Vol. IV, Issue 4, (2016) 289-304

11. Jung-Kook Song and Jong-Myon Bae. Citrus Fruit Intake and Breast Cancer Risk: A Quantitative Systematic Review. J Breast Cancer. 2013 Mar; 16(1): 72–76.

12. Carlos A. González, Núria Sala, Theodore Rokkas. Gastric Cancer: Epidemiologic Aspects. Helicobacter ISSN 1523-5378doi: 10.1111/hel.12082

13. Grapefruit and Medication. Total Health. 27 (2): 39. 2005.

14. Carr, Jackie. Five Ways to Prevent Kidney Stones. UC San Diego. April 22, 2010

15. A. Lichota et al. Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. European Journal of Medicinal Chemistry 176 (2019) 68-91

16. Bogucka – Kocka et al. Diosmin – Isolation Techniques, Determination in Plant Material and Pharmaceutical Formulations, and Clinical Use. Natural Product Communications Vol. 8 (4) 2013

17. Berne, Robert M, Bruce M. Koeppen, and Bruce A. Stanton. Berne & Levy physiology, Seventh Edition. Philadelphia, PA: Mosby/Elsevier, 2018

18. Hall, John E, and Arthur C. Guyton. Guyton and Hall Textbook of Medical Physiology, 13th edition. Philadelphia, PA: Elsevier, 2016

19. Overview of the Venous System. MSD Manual Consumer Version. Retrieved June 11th, 2016 (

20. Huether, Sue E.McCance, Kathryn L., eds. Understanding Pathophysiology. 6th edition. St. Louis, Mo.: Elsevier/Mosby, 2016

21. Heart and Blood Vessels Disorders. MSD Manual Consumer Version. Retrieved June 11th, 2016 (

22. Economos C, Clay WD. Nutritional and health benefits of citrus fruits. Food Nutr Agric. 1999;24:11–18

23. Morand C., Dubray C., Milenkovic D., et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. American Journal of Clinical Nutrition. 2011;93(1):73–80. doi: 10.3945/ajcn.110.004945

24. Zou Z., Xi W., Hu Y., Nie C., Zhou Z. Antioxidant activity of Citrus fruits. Food Chem. 2016;196:885–896. doi: 10.1016/j.foodchem.2015.09.072

25. Testai L., Calderone V. Nutraceutical value of citrus flavanones and their implications in cardiovascular disease. Nutrients. 2017;9:502. doi: 10.3390/nu9050502

26. Eklöf et al. Revised CEAP classification for chronic venous disorders: Consensus statement. JOURNAL OF VASCULAR SURGERY Volume 40, Number 6, 2004